| abstract |
The subject invention describes Novel dimer 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having the general Formula I: <IMAGE> +TR <IMAGE> wherein n is 1-5; R1 to R4 are independently selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, hydroxy, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkyl- or di-(C1-6 alkyl)amino, cyano, trifluoromethyl, nitro, trifluoromethylthio or trifluoromethylsulfonyloxy; R5 and R6 are independently hydrogen, or C1-6 alkyl; X is O, S, SO, SO2, CO or (CH2)m, m being 0 or 1, or X is NR7, R7 being H, C1-6 alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalkyl, or X is CR8R9, wherein R8 and R9 are independently selected from the group consisting of hydroxy and the substituents defined under R7, any phenyl group being optionally substituted with one or more substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, hydroxy, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkyl or di(C1-6 alkyl)amino, cyano, trifluoromethyl or trifluoromethylthio; and Z1 is O, S, (CH2)q, q being 1,2 or 3, or Z1 is CH2O, CH2S, CH2CH2O, CH2CH2S, CH=CH, CH=CHCH2, CH2OCH2 CH2SCH2, CH=CH-O, or CH=CH-S; and Z2 is O, S or (CH2)p, p being 0 or 1, with the proviso that Z1 may not be O, S or (CH2)q, wherein q is 1 when Z2 is (CH2)p wherein p is 0; or an acid addition salt thereof. These compounds are potent sigma receptor ligands thus being useful for the treatment of anxiety, psychosis, epilepsy, convulsion, movement disorders, motor disturbances, amnesia, cerebrovascular diseases senile dementia of the Alzheimer type or Parkinson's disease. |