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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
filingDate 1995-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2565e6f5b76ede14b34fc0f5dcbbd709
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publicationDate 1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5656738-A
titleOfInvention Inducible defensin peptide from mammalian epithelia
abstract The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.
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priorityDate 1994-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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