| abstract |
Disclosed is a novel alpha -glycosyl derivative of a catecholamine or its salt, said alpha -glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an alpha -glucosyl saccharide and one of catecholamines in order to form an alpha -glycosyl derivative of said catecholamines, and recovering the resultant alpha -glycosyl derivative. The alpha -glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the alpha -glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc. |