| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_067c1f6ec07067ca0b49b39431dd1631 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-285 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 |
| filingDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_652f46848ebb68fffeee832856a699ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ddbef51a5af1331196d1a6138bff45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3f324900ff89690072a73ea6b879adc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1880c966f80bbcff0e56e94830e884d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec68dced6fdaf2549bd7e222c3a7eade |
| publicationDate |
1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5656436-A |
| titleOfInvention |
Analog of Haemophilus Hin47 with reduced protease activity |
| abstract |
An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6054134-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180535-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087451-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11129906-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7015033-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878023-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9657085-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7081520-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003181679-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6218147-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9486513-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11219671-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10857233-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10364435-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9593339-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954521-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11485773-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10590185-B1 |
| priorityDate |
1994-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |