| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70567 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1995-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_522094b14112a8fed865f2cbc7c3206a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57137dd4780e2d84622549fce24a94ab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6de7d3ed4c26406a0df721199f2f971
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_feb2241e032eb7e53607096c12ba0e1e |
| publicationDate |
1997-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5654137-A |
| titleOfInvention |
Human CRABP-I and CRABP-II |
| abstract |
The sequences encoding two isoforms of human cellular retinoid acid binding proteins, CRABP-I and CRABP-II, have been cloned and sequenced and are set forth with their corresponding amino acid sequences. The identification of human CRABP nucleic and amino acid sequences provides the basis for the construction of recombinant human CRABP vectors and expression constructs. Human CRABP can also be synthesized or produced ex vivo, e.g. in bacterial or other production systems. Ligand binding assays, including recombinant and chimeric receptor reporter assays, and direct and competition hybridization assays employing the human CRABP sequences herein described can be used to test drugs for retinoid induction and tissue specificity for pathologies in which retinoids are implicated. Immunoassays utilizing antibodies or binding fragments produced to human CRABP can also be used to test patient tissues for the presence and levels of CRABP for diagnosis and to monitor treatment. The identification of the nucleic and amino acids sequences for human CRABP-I and CRABP-II also contributes to the elucidation of the function and interaction of the retinoid-binding proteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5955305-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9169305-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7026125-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7098310-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013157284-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6051692-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9732127-B2 |
| priorityDate |
1991-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |