| abstract |
Protein tyrosine kinase inhibitors are provided of formula (I): <IMAGE> (I) wherein R2 is H, OH, halo or O(C1-C4)alkyl; R2 is OH, halo or O(C1-C4)alkyl; R1 is <IMAGE> wherein R4 is H, OH, halo, CH2OH, C(O)CH3, C(O)N(R)2 wherein each R is H or (C1-C4)alkyl; or C(O)R wherein R6 is OH or O(C1-C4)alkyl; and R5 is OH, CH2OH, C(O)CH3, C(O)N(R)2 or C(O)R6; or a pharmaceutically acceptable salt thereof, which inhibit the pathological proliferation or growth of mammalian cells, such as cancer cells. |