| abstract |
PCT No. PCT/JP93/01886 Sec. 371 Date Jun. 29, 1995 Sec. 102(e) Date Jun. 29, 1995 PCT Filed Dec. 24, 1993 PCT Pub. No. WO94/14443 PCT Pub. Date Jul. 7, 1994The present invention relates to a new use of macrolide compounds of the formula (I): <IMAGE> (I) wherein each symbol is as defined in the specification, for preventing or treating cerebral ischemic disease, such as, brain damage caused by ischemia, such as cerebral infarction. So, they are useful when the following diseases or injury occur. That is, head injury, hemorrhage in brain such as subarachnoid hemorrhage or intracerebral hemorrhage, cerebral thrombosis, cerebral embolism, cardiac arrest, stroke, transient ischemic attacks (TIA), hypertensive encephalopathy and so on. |