| abstract |
PCT No. PCT/JP92/01420 Sec. 371 Date Jun. 27, 1994 Sec. 102(e) Date Jun. 27, 1994 PCT Filed Nov. 2, 1992 PCT Pub. No. WO93/09097 PCT Pub. Date May 13, 1993Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: <IMAGE> in which R1 represents a group of formula: -OR3 (wherein R3 represents a hydrogen atom or an alkyl group), -NR4R5 (wherein R4 and R5 each represents a hydrogen atom, an alkyl or alkoxy group), -NHCH(R6COR7 (wherein R6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R7 represents an alkyl group), -NHCH(R6)COOR8 (wherein R8 represents an alkyl group) or -NHCH(R6)CONR9R10 (wherein R9 and R10 each represents a hydrogen atom or an alkyl group, or NR9R10 together represent a heterocyclic ring group); and R2 represents a hydrogen atom, an alkyl or aralkyl group. |