| abstract |
The invention is concerned with the compounds having the formula <IMAGE> (I) <IMAGE> the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is C1-4alkyl; C1-4alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C1-4alkyl; Z is C=O or CHOH; and <IMAGE> is a radical of formula <IMAGE> (a-1) <IMAGE> (a-2) <IMAGE> (a-3) <IMAGE> (a-4) <IMAGE> (a-5) <IMAGE> (a-6) or <IMAGE> (a-7) Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine. |