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filingDate 1994-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1997-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5639619-A
titleOfInvention Screening assay for anti-HIV drugs using the Vpr gene
abstract The essential role of the Vpr protein of HIV in the progression of HIV infection is disclosed. Recognition of this role permits assay for potential drug candidates by virtue of their ability to interfere with the interaction of Vpr with its intracellular targets. Thus, cells that are modified to contain an expression system for the production of Vpr are cultured in the presence and absence of the drug candidate and the growth rates compared. The ability of a candidate to enhance the growth of a culture producing Vpr indicates its potential as an anti-AIDS therapeutic.
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