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filingDate 1995-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1997-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5627050-A
titleOfInvention Bone-related sulfatase-like protein and process for its production
abstract A bone-related protein named OSF-8 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of sulfatases. OSF-8 degrades the sulfate groups of the sugar chains of proteoglycan, which makes up the cartilage matrix, during the replacement of cartilage into bone tissue at the stage of osteogenesis. OSF-8 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
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