| abstract |
PCT No. PCT/JP93/00014 Sec. 371 Date Jan. 14, 1994 Sec. 102(e) Date Jan. 14, 1994 PCT Filed Jan. 8, 1993 PCT Pub. No. WO94/01442 PCT Pub. Date Jan. 20, 1994A methane diphosphonic acid derivative represented by the general formula (I): <IMAGE> (I) wherein, X and Y are defined in the specification; m represents an integer of 0 to 3; n represents an integer of 0 to 4; and each X of the (X)m and each Y of the (Y)n may be either identical or different; +E,uns . . .+EE represents a double bond or single bond; A is -(CH2)a-(D)b-(CH2)c- (wherein D is sulfur, oxygen, NH, alkyl-substituted N, or CH2, a and c are integers of 0 to 10 and b is 0 or 1), or -(CH=CH)d=CH= (wherein d is an integer of 0 to 2, and B does not exist when A represents -CH=CH)d-CH=), B refers to a hydrogen atom, alkyl group, amino group, monoalkylamino group, dialkylamino group, acylamino group, hydroxyl group, alkoxy group, trialkylsiloxy group or acyloxy group, and each of R1, R2, R3 and R4 is hydrogen atom, straight or branched alkyl group having 1 to 7 carbon atoms, or pharmacologically allowed cation, and these may be identical or different, as described. The compounds of the present invention have excellent IL-1 inhibitory action, antioxidative action and bone resorption inhibitory action, and are useful as an antiinflammatory drug, antirheumatic drug, or autoimmune disease drug. |