| abstract |
Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I <IMAGE> (I) wherein: R', R'', R''', Rx1, Rx2, Ry1, Ry2, Ry3, Ry4 and R0 are as defined hereinabove; and R2 is <IMAGE> R3 is <IMAGE> <IMAGE> <IMAGE> <IMAGE> R3a, R3b, R3c and R3d are independently hydrogen, C1-C12 alkyl, C2-C12 alkynyl, C1-C12 alkoxy, C1-C12 alkylthio, halo, or -O-(CH2)m-[O-(CH2)n]p-O-(C1-C12 alkyl) or -O-(CH2)q-X-R4; m is 2, 3 or 4; n is 2, 3 or 4; p is 0 or 1; q is 2, 3 or 4; X is pyrrolidino, piperidino or piperazino; and R4 is hydrogen, C1-C12 alkyl, C3-C12 cycloalkyl, benzyl or C3-C12 cycloalkylmethyl; or a pharmaceutically acceptable salt thereof. |