| abstract |
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R 1 , R 2 and R 3 each independently are hydrogen or C 1-4 alkyl; R 4 and R 5 each independently are hydrogen, halo, C 1-4 alkyl, C 1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R 6 is pyridinyl optionally substituted with up to two C 1-4 alkyl groups; di(C 1-4 alkyl) hydroxypyridinyl; di(C 1-4 alkyl)C 1-4 alkyloxypyridinyl; pyridazinyl optionally substituted with C 1-4 alkyloxy; pyrimidinyl optionally substituted with hydroxy or C 1-4 alkyloxy; thiazolyl optionally substituted with C 1-4 alkyl; thiadiazolyl optionally substituted with C 1-4 alkyl; benzoxazolyl or benzothiazolyl; or R 6 is pyrazinyl or pyridazinyl substituted with C 1-4 alkyl; Z is C═O or CHOH; and ##STR2## is a radical of formula ##STR3## Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine. |