| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43504
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e5cc3dd611d6d4281b200683bbecd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a4eee396c7b71d364d686b793dcf04f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64065a8a7247613368326c2a8b4c73cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55aa7baabf09b632ede2dc7dac75f9c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61e6d2af713c6a44480a7ea66bb8e548 |
| publicationDate |
1997-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5595972-A |
| titleOfInvention |
Conotoxin peptides |
| abstract |
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the alpha -conotoxin peptides. The A-lineage conotoxin peptides include the alpha -conotoxin peptides, the alpha -conotoxin-like peptides and the kappa -conotoxin peptides, described further below. The alpha -conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the alpha 3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 1). The alpha -conotoxin-like peptides generally share a core sequence termed the alpha 4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The kappa -conotoxin peptides generally have a core sequence termed the kappa 7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3) alpha -conotoxins MII (SEQ ID NO:54) and U002 (SEQ ID NO:10) preferentially bind to neuronal nicotinic acetylcholine receptors, rather than neuromuscular receptors. These latter two conotoxins can be used to diagnose and treat small-cell lung carcinomas, which have cholinergic nicotinic receptors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7785799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008268423-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02060923-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9824462-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7902153-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0044776-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010145011-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9803541-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004254477-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016122388-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6265541-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7666840-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004002582-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008081901-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02060923-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5780433-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6958323-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8487075-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8735541-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6797808-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004176278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633417-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004204362-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6958151-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7115708-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8513281-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8110549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5969096-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7279549-B2 |
| priorityDate |
1993-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |