| abstract |
A 2-halo-pyrimidine-4-carboxylic acid of formula: <IMAGE> I wherein X is a halogen atom, for example, 2-chloro-pyrimidine-4-carboxylic acid. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula: <IMAGE> III wherein R1 is a halogen atom, NH2-, HO- or a C1-C4 alkoxy group and R2 is a C1-C4 alkoxy group or a halogen atom with the proviso that, if R1 is a HO- group, R2 is not a halogen atom and with the proviso that, if R2 is a halo group, R1 is not an amino group. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula III wherein R1 is a HO- group and R2 is an ethoxy group. |