| abstract |
The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhythmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R 1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms, n R 2 is lower alkyl, and n R 3 is lower alkyl, or n R 2 and R 3 together form an alkylene chain having 3-6 carbon atoms, n R 4 ' is cyano, an R 6 --O--CO-- group in which R 6 is lower alkyl, an R 7 --SO 2 --NH-- group in which R 7 is lower alkyl, or an R 8 --CO--NH-- group in which R 8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro or an R 9 --SO 2 -- radical in which R 9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, and n R 5 is hydrogen or halogen, n and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them. |