| abstract |
The invention provides pharmaceutical compounds of the formula: <IMAGE> in which A - - - B is CH2-CH2 or CH=CH; X is a pyridine or benzene ring; when X is pyridine n is 0; when x is benzene n is 0, 1 or 2 and when A - - - B is CH2-CH2. R1 is attached at any of the positions 7 to 10, and when A - - - B is CH=CH, R1 is attached at any of the positions 5 to 10; each R1 is halo, carboxy, trifluoromethyl, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, hydroxy-C1-4 alkyl, hydroxy-C1-4 alkoxy, nitrogen-containing heterocyclyl, nitro, trifluoromethoxy, -COOR5 where -R5 is an ester group, -COR6, -CONR6R7 or -NR6R7 where R6 and R7 are each hydrogen or C1-4 alkyl; R2 is phenyl, naphthyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl, naphthyl and heteroaryl groups being optionally substituted, or R2 is furanyl optionally substituted with C1-4 alkyl; R3 is nitrile, carboxy, -COOR8 where R8 is an ester group, -CONR9R10 where R9 and R10 and each hydrogen or C1-4 alkyl, or -SO2R11 where R11 is C1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl; and R4 is 1-pyrrolyl, 1-imidazolyl or 1-pyrazolyl, said 1-pyrrolyl, 1-imidazolyl and 1-pyrazolyl being optionally substituted by one or two C1-4 alkyl, carboxyl, hydroxy-C1-4 alkyl or -CHO groups, or 1-(1,2,4-triazolyl), 1-(1,3,4-triazolyl) or 2-(1,2,3-triazolyl), said triazolyl groups being optionally substituted by a C1-4 alkyl or C1-4 perfluoroalkyl group, or 1-tetrazolyl optionally substituted by C1-4 alkyl; and salts thereof. |