| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
1993-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1996-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42d30f350892a2fb8fa3d416e59e831e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52fc881e027e781932e4dcba9c3adde |
| publicationDate |
1996-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5571510-A |
| titleOfInvention |
Method for selective methionine starvation of malignant cells in mammals |
| abstract |
An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine gamma -lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009259303-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004127435-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006063172-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8796241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003129262-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002146695-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007161025-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5891704-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6911309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1316611-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1316611-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6461851-B1 |
| priorityDate |
1993-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |