| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate |
1994-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1996-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31e68ba80cf28f70801a1d9c5d752e59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb1e1409245c53163864711d6179743d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75ad78599cac192f584a1c704647cda4 |
| publicationDate |
1996-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5567693-A |
| titleOfInvention |
Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| abstract |
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-(hydrogen or di (C1-C4)alkylamino)-8-halogen-9-(substituted)-6-demethyl-6-deoxytetracycline of Formula I: <IMAGE> Formula I wherein R, X and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007270389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007243244-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003104573-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7820641-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004224928-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004002481-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7053041-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470804-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6537554-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5837696-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8168810-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8492365-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6429204-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088755-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137845-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7595309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011118215-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004138183-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007155708-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008014256-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9533943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8466132-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6946453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7456158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7521437-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6638922-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5856315-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010075929-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851460-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8252777-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6894036-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006194773-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009306022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5843925-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6100248-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7696186-B2 |
| priorityDate |
1994-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |