| abstract |
The invention relates to derivatives of pyrrolidin-2-ylcarbonylheterocyclic compound of the general formula <IMAGE> in which R1 represents C1-6 alkyl, C1-20 cycloalkyl, aryl or heteroaryl, R2 represents a heterocyclic compound selected from the group consisting of 2-thiazole, 2-oxazole, 2-imidazole, 2-pyrrole, 2-thiophene, 2-benzothiazole, 2-benzoxazole, 2-benzimidazole, 2-indole, 2-thiazolo[5,4-b]pyridine, 2-oxazolo[4,5-b]pyridine, 2-imidazo[4,5-b]pyridine, 5-thiazole, 2-thiazoline, 2-pyridine, 3-pyridine, 5-pyrimidine, 2-pyrazine, 2-triazole or 2-pyrazole wherein the heterocyclic compound may be unsubstituted or substituted independently with R4 or R5 wherein R4 and R5 are H, C1-5 alkyl, aryl or R4 and R5 may be ortho substituents on the heterocyclic compounds and connected to form an aryl or heteroaryl ring, A represents a cyclic amino acid, X is oxygen atom, thiomethlene or methylene residue, m is an integer from 1 to 5, to a process for the preparation thereof, to composition containing them, and to the use thereof. |