| abstract |
PCT No. PCT/EP92/01790 Sec. 371 Date Feb. 23, 1994 Sec. 102(e) Date Feb. 23, 1994 PCT Filed Aug. 6, 1992 PCT Pub. No. WO93/05074 PCT Pub. Date Mar. 18, 1993A natural dermatan sulphate with antithrombinic activity in excess of 220 U/mg which comprises an oligosaccharide sequence with a high degree of sulfation, having formula (III) <IMAGE> (III)n=integers 1 or 2; R4=SO3, or H; R6=H, or SO3; G=glucuronic acid: I-non-sulfated uronic acid, preferably glucuronic acid, is extracted from organs, and subsequently purified in mild operating conditions, at pH 5-7, isolation and fractionation being carried out with macroreticular ion exchange resins, having a particle size of less than 10 mu . |