http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5543406-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21f23f0c43864bd4d632cd6023e4a66a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-63 |
| filingDate | 1992-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e6c8e0ce2a0c60154d37f4755c368a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_519026715ed3d90050d87597a16f476f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0521c80ca9ee71635ed960518b5cc3e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f4e608623d0ad76139ca3222b4ef240 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b340f1c9b6733f3cbd398bfbdf47780d |
| publicationDate | 1996-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5543406-A |
| titleOfInvention | Inhibitors of 5-α-testosterone reductase |
| abstract | PCT No. PCT/US92/11109 Sec. 371 Date Aug. 15, 1994 Sec. 102(e) Date Aug. 15, 1994 PCT Filed Dec. 18, 1992 PCT Pub. No. WO/9313124 PCT Pub. Date Jul. 8, 1993The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) <IMAGE> (I) <IMAGE> (IG) wherein R1 and R2 are i) independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R1 and R2 is a single bond; R3c is hydrogen; R4c is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, alkanoyl of 2-6 carbons, -(CH2)mCO2R16, -(CH2)mAra, -(CH2)n'CONR17R18, -(CH2)n'NR17R18 or -(CH2)n'OR16, wherein R16 is hydrogen, lower alkyl or lower alkenyl; R17 and R18 are independently hydrogen, lower alkyl lower cycloalkyl or lower alkenyl; Ara is an aromatic group of 6 to 12 carbons; n' is 0 or an integer from 1 to 5; m is an integer from 1 to 5; R19 and R20 are independently hydrogen or lower alkyl, or taken together R19 and R20 form a carbonyl group (=O); R5c is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, or NR21R22, wherein R21 and R22 are independently hydrogen, lower alkyl or lower alkenyl; and pharmaceutically acceptable salts thereof, their preparation, medical use and pharmaceutical formulations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7115745-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005107427-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5935968-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6352997-B1 |
| priorityDate | 1991-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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