| abstract |
A method and composition for treating multidrug resistance in a mammal, in which the composition includes NDGA or an analog of NDGA in accordance with the following formula: ##STR1## wherein R 1 and R 2 are independently H, lower alkyl or lower acyl; n R 3 , R 4 , R 5 , and R 6 are independently H or lower alkyl; n R 7 , R 8 and R 9 are independently H, hydroxy, lower alkoxy or lower acyloxy; and n R 10 , R 11 , R 12 and R 13 are independently H or lower alkyl, in a pharmaceutically acceptable vehicle. n The method is particularly suitable for administering an antineoplastic agent, and the composition includes the combination of NDGA, or an analog with such an antineoplastic agent. |