| abstract |
This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and bronchoconstriction and inhibits the oxidation of LDL which is implicated in formation of atherosclerotic plaque. The compounds useful in this invention are represented by the formula: <IMAGE> wherein: R2 is hydrogen, halogen or C1-C6 alkyl; Y of O or S;R5 is hydrogen or methyl R6 is -NH2, -CH3 or -OCH3; and R1 is <IMAGE> <IMAGE> or <IMAGE> wherein R7, R8 and R10 are independently halogen, trifluoromethyl, alkyl, alkoxy, methanesulfonyl or trifluoromethanesulfonyl; R9 is hydrogen or methyl; and Z is O or S, or a pharmaceutically acceptable salt thereof. |