| abstract |
##STR1## wherein R and R 1 are each, independently, hydrogen, or ##STR2## R 2 and R 3 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, --CO 2 R 5 , --COR 5 , --CN, --NO 2 , --SO 2 R 5 , --SO 3 R 5 , --OR 5 , --SR 5 , or Ar; n R 4 is hydrogen, alkyl, alkenyl, alkynyl, --CF 3 , --NR 5 R 6 , --CO 2 R 5 , --COR 5 , CONR 5 R 6 , --NO 2 , halogen, --OR 5 , --SR 5 , --CN, --SO 2 R 5 , --SO 3 R 5 , --SO 2 NR 5 R 6 , or Ar; n R 5 and R 6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, or Ar; n Ar is phenyl, naphthyl, or hetaryl, wherein the foregoing may be optionally substituted; with the proviso that R and R 1 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent. |