http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5541062-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d43c883aa035c2b0560e1968520554fd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6454 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate | 1993-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11874be38070eb044ba693380d97ca23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81e0369353d30be99c71ab9253a142ed |
| publicationDate | 1996-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5541062-A |
| titleOfInvention | Methods and compositions for preparing protein processing enzymes |
| abstract | The present invention relates to a new protein, convertin I, which belongs to a family of mammalian convertase proteins characterized by partial amino acid sequence homology to each of the following: the precursor processing endoprotease of yeast KEX2, bacterial subtilisins, and the human fur gene product, furin. The protein which is a subject of this invention is further characterized as a mammalian convertase, which is capable of hydrolytically cleaving, for example, prohormones to yield active hormones. Specifically, convertin I is capable of cleaving peptide bonds following certain sequences of two adjacent basic amino acids. Convertin I has a molecular weight of approximately 70 kd by electrophoresis. Another aspect of this invention is a recombinant vector, incorporating the coding sequences which are the objects of this invention. Methods of preparing the endoprotease protein, including molecular engineering methods are described. This invention also relates to a nucleic acid segment, including DNA and a cDNA having a sequence coding for convertin I. Methods of detection of said protein by, for example, fluorescent antibodies, and use of its coding sequences as hybridization probes are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8140148-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5952463-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6077662-A |
| priorityDate | 1990-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 726.