abstract |
PCT No. PCT/FI91/00223 Sec. 371 Date Mar. 19, 1993 Sec. 102(e) Date Mar. 19, 1993 PCT Filed Jul. 22, 1991 PCT Pub. No. WO92/01936 PCT Pub. Date Jun. 2, 1992.According to the method of the invention, immunoassays are applied to measure free PSA as well as a proteinase inhibitor complex. Free PSA and PSA complex are according to the invention measured by a non-competitive immunoassay employing at least two different antibodies. The invention is further characterized in that the PSA proteinase inhibitor complex of interest is formed with alpha 1-antichymotrypsin. Moreover, the invention is characterized in that free PSA, the PSA-proteinase inhibitor complex and their ratio are applied in the diagnosis of patients with prostate cancer. |