http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5495044-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34cd20c171d27cfc98de08d1eb461a3a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195 |
| filingDate | 1993-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8704c4b52b684aa765953578fe331c49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d43b8ccbae31639545d963f0580fc65b |
| publicationDate | 1996-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5495044-A |
| titleOfInvention | Inhibitors of kynureninase |
| abstract | The present invention provides inhibitors of kynureninase having the formula ##STR1## where X is CO or CHOH; R A and R B , independently of one another, are H, a halogen, a halovinyl group, or a small alkyl or haloalkyl group having one to three carbon atoms; A is a H or an acetyl group; R 1 is H, NH 2 , NR 6 R 7 , NO 2 , halogen, CF 3 or a small alkyl group having from one to three carbon atoms, wherein: R 6 and R 7 , independently of one another, are H, a formyl group or a small alkyl group having from one to three carbon atoms with the exception that only one of R 6 or R 7 can be a formyl group; R 2 is OH, H, halogen, CF 3 or a small alkyl group having from one to three carbon atoms; and R 3 , R 4 and R 5 , independently of one another, are H, halogen, CF 3 , NO 2 , NH 2 , or small alkyl group having from one to three carbon atoms, and with the proviso that when X=CO, neither R A nor R B can be CF 3 . In compounds of this formula in which X is CHOH, those having the (αS,γS) configuration or the (αR,γR) configuration when R A or R B is a hydrogen, are more potent inhibitors of kynureninase. Inhibitors of mammalian kynureninase are of particular use in therapy for certain neurological disorders. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6207709-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5786508-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020011653-A1 |
| priorityDate | 1991-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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