| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07ba5e7ff356b7eda43fdfc20eef4b0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-822 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-16 |
| filingDate |
1994-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1996-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca62c4198fd5db9bca2337cc3baf568
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17b04c103405fdc40e680deb922a689a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31da437a456c38d8a1dd4fc5615d82ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e95a60f9983c7ee9e826215d054bef2e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37713979e053afdf402f9b0ea21cd00e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef8be4646f520c4698419b4887f45c42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46a020c5943679ff28164ffd87a8576d |
| publicationDate |
1996-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5492839-A |
| titleOfInvention |
Immunogenic ryanodine derivative and related uses |
| abstract |
Disclosed is a novel photo-activatable derivative of ryanodine 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine. This novel ryanodine derivative has been conjugated to keyhole limpet hemocyanin (KLH) and used for the production of antibodies with high affinity and specificity to ryanodine. A radioimmunoassay specific for ryanodine was developed using the anti-ryanodine antibodies, and a dissociation constant for ryanodine of 1 nM was determined. Also disclosed is the binding of a labeled, photoactivatable derivative of ryanodine (ABRy) with the ryanodine receptor of skeletal, cardiac and brain membranes. Digestion of the labeled ryanodine receptor revealed a labeled 76 kDa tryptic fragment which is critical for the formation of the high affinity ryanodine binding site. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005153460-A1 |
| priorityDate |
1994-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |