| abstract |
A compound of the structure <IMAGE> II wherein R1 and R2 are each, independently, hydrogen, or -CONH-O-(CR3R4)mZ; R3 and R4 are each, independently, hydrogen, alkyl, cycloalkyl, -CF3, or F; Z is hydrogen, alkyl, -OR5, -SR5, -NR5R6, -CN, -CF3, -OAr, -Ar, or R7; R5 and R6 are each, independently, hydrogen, alkyl, arylalkyl, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl, or Ar; R7 is <IMAGE> or -C 3BOND C-R11; R8, R9, R10, and R11 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, or phenyl, wherein the phenyl group may be optionally mono-, di-, or tri-substituted; Ar is an aryl radical that may be optionally mono-, di-, or tri-substituted; and m=1-6; with the proviso that R1 and R2 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent. |