| abstract |
Novel 2,9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-ones having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein n Alk represents C 1-4 alkanediyl, n D is a bicyclic heterocycle of formula ##STR2## wherein R 1 represents C 1-4 alkyl, hydroxyC 1-4 alkyl, carboxaldehyde, carboxyl, C 1-10 alkylcarbonyloxyC 1-4 alkyl; each R 2 represents hydrogen or C 1-4 alkyl; R 3 represents C 1-4 alkyl, hydroxyC 1-4 alkyl or methyl substituted with phenyl, 5-methyl-2-furanyl or 3-pyridinyl; and R 4 represents C 1-3 alkyl, phenyl, 5-methyl-2-furanyl or 3-pyridinyl. |