| abstract |
Therapeutic compounds have the formula: (X)j-(non-cyclic core moiety), j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate, hydrate, or salt of: <IMAGE> *C is a chiral carbon atom, n is an integer from one to four (preferably from one to three), one or more carbon atoms of (CH2)n may be substituted by a keto or hydroxy group, and m is an integer from one to fourteen. Independently, R1 and R2 may be a hydrogen, a straight or branched chain alkane or alkene of up to twelve carbon atoms in length, or -(CH2)wR5, w being an integer from two to fourteen and R5 being a mono-, di- or tri-substituted or unsubstituted aryl group, substituents on R5 being hydroxy, chloro, fluoro, bromo, or C1-6 alkoxy. Or jointly, R1 and R2 form a substituted or unsubstituted, saturated or unsaturated heterocyclic group having from four to eight carbon atoms, N being a hetero atom. R3 is a hydrogen or C1-3. Or, therapeutic compounds may also have the formula: <IMAGE> R4 is a hydrogen, a straight or branched chain alkane or alkene of up to eight carbon atoms in length, -(CH2)wR5, w being an integer from two to fourteen and R5 being a mono-, di- or tri-substituted or unsubstituted aryl group, substituents on R5 being hydroxy, chloro, fluoro, bromo, or C1-6 alkoxy, or a substituted or unsubstituted, saturated or unsaturated heterocyclic group having from four to eight carbon atoms. r and s are independently integers from one to four, the sum (r+s) not being greater than five. t is an integer from one to fourteen and one or more carbon atoms of (CH2)s or (CH2)t may be substituted by a keto or hydroxy group. |