| abstract |
Bi-aromatic esters have the formula <IMAGE> (I) wherein R1 represents H, OH, -CH3, -CH2OH, -CH(OH)CH3, -COOR9, <IMAGE> or SO2R10; R9 represents H, C1-C6 alkyl or mono or polyhydroxyalkyl; R10 represents OH, C1-C6 alkyl or <IMAGE> r' and r'' represent H, C1-C6 alkyl, aryl, aralkyl, mono or polyhydroxyalkyl, or r' and r'' taken together form a heterocycle; R2 represents H, C1-C6 alkyl, OR9, F or -CF3; R3, R4 and R5 represent H, F, OH, -CH3, -OCH3, -CF3, -COOH or -CH2OH; R6 and R8 represent H, alpha -substituted C3-C15 alkyl, alpha , alpha '-disubstituted C4-C12 alkyl, C3-C12 cycloalkyl, C5-C12 mono or polycyclic cycloalkyl whose linking carbon is trisubstituted, -SR11, -SO2R11 or -SOR11; R11 represents C1-C6 alkyl or cycloalkyl; R6 and R8 cannot simultaneously represent H; R7 represents H, C1-C6 alkyl, alkenyl, alkenyloxy, OR12 or SR13; R12 represents H, C1-C6 alkyl or alkenyl; R3 represents H, C1-C6 alkyl or aralkyl; with the proviso that when R1 represents <IMAGE> and R2 represents H then: (i) either R3 and R4 are other than H or -CH3, (ii) or R7 is other than OR12 and R6 or R8 is cycloalkyl having more than 7 carbon atoms, (iii) or R7 is OR12 but R6 and R8 are other than H, (iv) or R7 is OR12 but R5 is other than H. The bi-aromatic esters are employed in human and veterinary medicine and in cosmetic compositions. |