http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5459154-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 |
| filingDate | 1993-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6eca1cd4e53a624756dfdd432fe50e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b5ee6eae9d60957f1cfe9c74b5beb45 |
| publicationDate | 1995-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5459154-A |
| titleOfInvention | N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein |
| abstract | This invention relates to compounds having 5-lipoxygenase inhibiting properties and inhibition of oxidative modification of low density lipoprotein which have the formula: <IMAGE> wherein: R1 and R3 are independently hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl, or C1-C6 trifluoroalkoxy; R2 is hydrogen or methyl; R4 is hydrogen, methyl or hydroxy; R5 is hydrogen, -NH2, C1-C6 alkyl, aryl, aralkyl, or -N=C(CH3)2; X and Y are independently O or S; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. Compounds which inhibit 5-lipoxygenase are useful in the treatment of diseases mediated by leukotrienes such as inflammation or bronchoconstriction. Compounds which inhibit oxidative metabolism of low density lipoprotein are useful in the inhibition of atherosclerotic plaque formation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3791880-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4008327-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5646168-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5763467-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006006832-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007254882-A1 |
| priorityDate | 1993-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 405.