| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_111ec27d2e874cd8c4b404ff4f39f89d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 |
| filingDate |
1995-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_643f346a64f2fa29329903901fb2ca14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af345830552f1a16de2b62cd779d7911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_066a2f7f7e039052824633be9981d078 |
| publicationDate |
1995-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5455049-A |
| titleOfInvention |
Terfenadine oral powder |
| abstract |
The present invention contemplates a dry, powdered terfenadine composition. That composition comprises (a) a mixture of: (i) about 1 to about 20 parts by weight micronized terfenadine and (ii) about 0.2 to about 10 parts by weight a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer having an HLB number of 24 that is a wetting agent for said terfenadine; that are dry-blendedly dispersed into: (b) about 20 to about 40 parts by weight spray-dried sorbitol particles that are loosely packed, randomly oriented filamentary crystals having pores that entrap said terfenadine particles and wetting agent upon said dry-blended dispersal, said components being further dry blended with (c) about 2 to about 10 parts by weight dry polyvinylpyrrolidone; (d) about 1 to about 5 parts by weight of a dry mixture of microcrystalline cellulose and sodium carboxymethylcellulose; and (e) a dry flavorant in an amount sufficient to provide a desired taste to said powder; said composition being a free-flowing powder that is substantially free from the taste of terfenadine when placed on the human tongue in dry form or when dispersed in water and tasted within about five minutes of said dispersal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03053403-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1116485-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6645529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006013834-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5962461-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007281013-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006205616-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10995112-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0151026-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6753009-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003157172-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7638477-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007281014-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0151026-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8637076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017168-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2135611-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5763449-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03053403-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2471536-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9101160-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1116485-A3 |
| priorityDate |
1995-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |