| abstract |
PCT No. PCT/GB90/01117 Sec. 371 Date Jan. 16, 1992 Sec. 102(e) Date Jan. 16, 1992 PCT Filed Jul. 20, 1990 PCT Pub. No. WO91/02716 PCT Pub. Date Mar. 7, 1991.Compounds of general formula I: <IMAGE> (I) are presented that have collagenase inhibition activity and are useful in the management of disease involving the tissue degradation and the promotion of would healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumor invasion. |