| abstract |
Compounds of formula (I) <IMAGE> (I) wherein R represents a <IMAGE> group in which R2 is a hydrogen atom, a (C1-C4)alkoxycarbonyl group, a carboxylic group, a sodium carboxylate group, a -CH2OR4 group R4 being a hydrogen atom or a (C1-C4)alkyl group or a (C1-C4)acyl group, an amide group of the formula -CONR5R6, or a -CN4R5 group, R5 being a hydrogen atom or a (C1-C4)alkyl group and R6 being a hydrogen atom, a (C1-C4)alkyl group, a hydroxy group or a (C1-C4)alkoxy group, and R3 is a (C1-C4)alkyl group, R1 represents either a hydrogen atom or a (C1-C4)alkyl group, X represents either a sulphur atom, an oxygen atom or a methylene group, n=1 or 2 and Ar represents either a naphthalen-1-yl group substituted by a di(C1-C4)alkylamino group, or a 6,7-di(C1-C4)alkoxynaphthalen-1-yl group, or a quinolin-8-yl group substituted at 3 by a (C1-C4)alkyl group, or a 1,2,3,4-tetrahydroquinolin-8-yl group substituted at 3 by a (C1-C4)alkyl, or a 1H-indazol-7-yl group and pharmaceutically acceptable organic or inorganic salts thereof. Application in therapy. |