http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5451604-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-42 |
| filingDate | 1993-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e2818ac26f3e2f1021d3cd524f5914d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74cd76e2c6f2714a316413474cfa3914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c811132cfc8a51bf94072af68c439cb0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff6f957af285d97a935e06603ff32131 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f8f0a8979863ea854cfc61eeaba405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b684a7a6cc0efa78a13e74fbbae48ee |
| publicationDate | 1995-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5451604-A |
| titleOfInvention | Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives |
| abstract | A class of halogenated phenylacetonitrile alkylaminoalkylphenyl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases. Compounds of particular interest are of the formula <IMAGE> wherein m is a number selected from three to five, inclusive; wherein n one or two; wherein R1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, iso-butyl, n-pentyl, isopentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, benzyl and phenethyl; wherein R2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, iso-butyl, n-pentyl, isopentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, benzyl and phenethyl; wherein each of R3 through R7 is selected from hydrido, fluoro, chloro, bromo, azide, trifluoromethyl, difluorochloromethyl, 1,1-difluoroethyl, 2,2,2-trifluoroethyl, perfluoroethyl and 2,2,2,3-tetrafluoropropyl; with the proviso that at least one of R3 through R7 is selected from fluoro and trifluoromethyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2583678-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10010524-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10010523-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9463179-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010190852-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9737503-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008266798-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10010522-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2170050-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9227918-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2170050-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6265439-B1 |
| priorityDate | 1993-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1333.