| abstract |
A class of N-substituted ( alpha -imidazolyltoluyl)pyrrole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula <IMAGE> wherein m is one; wherein R0 is selected from CH2OH, CO2H, CHO, CO2CH3, CO2C2H5, CH2OCH3, CH2OCHOCH3 and CH2-CO2C2H5; wherein R1 is selected from Cl, CF3, CHO, n-butyl, cyano, CO2CH3 and CO2CH2CH3; wherein R2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, propylthio, butylthio and hydroxyalkyl; wherein each of R3, R4, R6, R7, R9 and R10 is hydrido; wherein each of R5 and R8 is independently selected from hydrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl, methoxycarbonyl with the proviso that at least one of R5 and R8 is an acidic group selected from CO2H and tetrazolyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure. |