| abstract |
PCT No. PCT/EP92/01483 Sec. 371 Date Jan. 5, 1994 Sec. 102(e) Date Jan. 5, 1994 PCT Filed Jul. 1, 1992 PCT Pub. No. WO93/01186 PCT Pub. Date Jan. 21, 1993. <IMAGE> (I) Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R1 and R2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R3 is hydrogen, hydroxy or alkoxy; "Het" is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R4 and R5, which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain. |