http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5438149-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_315ae544538aaeac6d1f4eed6754e4bb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 |
| filingDate | 1994-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b37fcfe5dc853d6675c1afa983d75bb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c697455e1509a4439c697f8fc949c52 |
| publicationDate | 1995-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5438149-A |
| titleOfInvention | Difluoromethylation of a phenyl triazolinone |
| abstract | An improved process for the difluoromethylation of a 1-phenyl-1H-1,2,4-triazol-5-one at the 4-position of the triazole ring with chlorodifluoromethane significantly reduces the amount of base required for the process, thereby reducing the environmental impact of the process by reducing the amount of by-product salts in the waste stream. The improvement comprises reacting the triazolinone with potassium carbonate in a solvent such as dimethylformamide, at a carbonate to triazolinone ratio in the range of about 0.55 to 1.0; reducing the water content of the reaction mixture to below about 2400 ppm by distillation; heating the reaction mixture in a sealed autoclave to 110 DEG to 180 DEG C., adding a 10 to 15 percent molar excess of chlorodifluoromethane, heating the reaction mixture at a temperature of 140 DEG to 210 DEG C. for 5 to 60 minutes, and recovering the difluoromethylated triazolinone. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0889882-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0889882-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007236475-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6218545-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9395905-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103183645-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104326992-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0012490-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5756755-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2789077-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004252109-A1 |
| priorityDate | 1994-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.