| abstract |
The invention relates to 9-deoxo-9a-aza-11-deoxy-9a-homoerythromycin A 9a,11-cyclic carbamates, novel semisynthetic macrolide antibiotics from the genus of azalides, of the formula (I) ##STR1## wherein n n R.sup.1 ═R.sup.2 ═CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 n n ═R 4 ═CH 3 , (IA) n n R.sup.1 ═R.sup.2 ═CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 n n ═CH 3 , R 4 ═H, (IB) n n R.sup.1 ═R.sup.2 ═CO.sub.2 CH.sub.2 C.sub.6 H.sub.5, R.sup.3 n n ═R 4 ═H, (IC) n n R.sup.1 ═R.sup.2 ═H, R.sup.3 ═R.sup.4 ═CH.sub.3,(ID) n n n R.sup.1 ═R.sup.2 ═R.sup.4 ═H, R.sup.3 ═CH.sub.3,(IE) n n n R.sup.1 ═R.sup.2 ═R.sup.3 ═R.sup.4 ═H, (IF) n n n R.sup.1 ═H, R.sup.2 ═R.sup.3 ═R.sup.4 ═CH.sub.3,(IG) n n n R.sup.1 ═R.sup.4 ═H, R.sup.2 ═R.sup.3 ═CH.sub.3,(IH) n n n R.sup.1 ═R.sup.3 ═R.sup.4 ═H, R.sup.2 ═CH.sub.3,(IJ) n n to pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to intermediates and to processes for the preparation thereof, to a process for preparing pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in treatment of bacterial infections. |