| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e019980e0d3964666d42b84f16f7fe2a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0075 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-10 |
| filingDate |
1993-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9f271b6ae4e5179edfcd4b2f45ffc5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3690fabc0aab4cf20c27190fd5962050
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f724f57317a8d0c0c772914c45960e00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef45db84848cda2b99c412d2b0285ed9 |
| publicationDate |
1995-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5430133-A |
| titleOfInvention |
Semi-synthetic glycosaminoglycans with heparin or heparan structure of α-L-iduronic-2-O-sulfate acid modified in position 2 |
| abstract |
New heparin and heparan sulfate derivatives having antithrombotic activity, also endowed with reduced haemorrhagic and anticoagulant activity, are obtained by nucleophilic addition to heparin and heparan sulfate derivatives containing 2,3-anhydrogulonic acid residues. The compounds have the formula IV ##STR1## The glycosaminoglycan derivatives obtained through this treatment show a structural modification in the unit of α-L-iduronic acid 2-O-sulfate with the partial or total selective substitution of the O-sulfate group in position 2 with a nucleophilic residue. The structural modifications produce an improvement of the biological properties of the heparin and heparan sulfate, substantially keeping the antithrombotic activity while diminishing the haemorragic effect in vivo and the anticoagulant activity in vitro. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9139876-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102011077393-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008119438-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8715953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011207919-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7575886-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004038932-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8435795-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9068957-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540454-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7259152-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009061411-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10022394-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006240473-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947507-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003203385-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6255295-B1 |
| priorityDate |
1992-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |