http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5426228-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 |
| filingDate | 1994-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10fa9e53664afdc16bcb08bc8caefd54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8594660637c0600f4c65c058c1d17d44 |
| publicationDate | 1995-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5426228-A |
| titleOfInvention | General method for preparation of sphingosine bases and their analogues |
| abstract | Described herein is a novel method of preparing selectively diastereomers of sphingosine bases and their analogues of general formula (1a) or (1b) ##STR1## where R is an aliphatic or aromatic substituent containing a straight, branched or cyclic chain, which may include one or several heteroatoms as chain members and one or several functional groups as substituents. The method comprises the steps of: n a) converting a starting material into an intermediate product in the form of α,β-unsaturated ketone having the general formula (4a) or (4b) ##STR2## where R is as defined above and PG are any protecting groups compatible with the method, n b) reducing said α,β-unsaturated ketone to an aminoalcohol with DIBAL in toluene to obtain selectively an anti-diastereomer, and n c) removing the protecting groups to obtain the free sphingosine base or its analogue according to formula (1a) or (1b). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010085547-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE38793-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7960589-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010085547-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010197954-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107520-A |
| priorityDate | 1994-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.