| abstract |
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: <IMAGE> I wherein A is selected from <IMAGE> <IMAGE> wherein each of R1 and R2 is independently selected from hydrido, methyl, ethyl, fluoro, hydroxymethyl, carbomethoxy, trifluoromethyl, carboxyl and fluoromethyl; wherein each of R3, R4, R6 through R9, R11 and R12 is independently selected from hydrido, methyl, fluoro and chloro; and wherein each of R5 and R10 is independently selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, methoxy, methylthio, cyano, trifluoromethyl, hydroxymethyl, methoxymethyl, methylsulfonyl and sulfamyl; provided that when A is <IMAGE> R5 cannot be hydrido when R10 is selected from hydrido, cyano, halo, methyl, trifluoromethyl and methoxy.; further provided that R10 cannot be hydrido when R5 is selected from cyano, halo, methyl, trifluoromethyl and methoxy; and further provided that R5 and R10 are not both methoxy; or a pharmaceutically suitable salt thereof. |