abstract |
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula <IMAGE> (I) wherein R1 and R3 are independently hydrogen, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof. |