| abstract |
2,3-Dideoxy-2,2-di(organothio)-B-D-pentofuranosyl-pyrimidines are disclosed as intermediates in the synthesis of 2', 3'-dideoxynucleosides and have the structure shown below. ##STR1## wherein R 4 is a hydroxyl protecting group; n X is oxygen or nitrogen, said nitrogen being bonded to a hydrogen atom, an alkyl or acyl group; n Y is hydrogen, halogen, alkyl, haloalkyl or haloalkenyl; and n R 5 is alkyl, aralkyl, or aryl wherein aralkkyl or aryl is substituted with hydrogen, halogen, nitro or alkoxy. n 2', 3'-Dideoxynucleosides, products of the above intermediates, are useful as antiviral agents. |