| abstract |
Leukotriene-B 4 derivatives of formula I ##STR1## are described, in which R 1 means CH 2 OH, CH 3 , CF 3 , COOR 5 , CONR 6 R 7 , or n R 1 together with R 2 means a carbonyl group, n R 4 symbolizes H, C 1 -C 10 alkyl optionally substituted, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl radical optionally substituted, or a 5-6-membered aromatic heterocyclic ring, n A symbolizes a trans, trans-CH═CH--CH═CH, a --CH 2 CH 2 --CH═CH-- or a tetramethylene group, n B symbolizes a C 1 -C 10 alkylene group, which optionally can be substituted by fluorine or the group ##STR2## D can mean a direct bond, oxygen, sulfur, --C.tbd.C--, --CH═CR 6 or together with n B can also mean a direct bond, their salts with physiologically compatible bases and their cyclodextrin clathrates. |