| abstract |
Novel allosamidin compounds, AJI9463A, AJI9463B and AJI9463C, represented by the following structural formula (1): <IMAGE> (1) <IMAGE> wherein R1 and R2 are hydrogen and R3 is hydroxy (AJI9463A); R1 and R3 are hydrogen and R2 is hydroxy (AJI9463B); and R1 is methyl, R2 is hydroxy and R3 is hydrogen (AJI9463C), exhibit extremely potent inhibitory activity against chitinases from a number of sources, particularly from Candida albicans, and can be utilized as potent antifungal agents and chitinase inhibitors. Pseudo disaccharide compounds, obtained by partial hydrolysis of these compounds with an acid, also show potent inhibitory activity against chitinase, and can be utilized as antifungal agents and chitinase inhibitors. |